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A randomized, double-blind, placebo-controlled crossover trial examining acute effects of the thermogenic supplement OxyShred on resting energy expenditure, cardiovascular markers, and subjective mood states.
Participants: 23 healthy female college students, ages 18-40, BMI 25-32.5
Design: Randomized, double-blind, placebo-controlled crossover
Testing: Baseline, then 30, 60, 120, and 180 minutes post-ingestion
Primary outcomes: REE, hemodynamics, blood markers, mood
Determine whether a thermogenic supplement alters metabolic rate, hemodynamic responses, and mood states.
One serving of OxyShred (caffeine, micronutrients, and phytochemicals) vs. placebo.
Active treatment increased resting energy expenditure for up to 3 hours without adverse hemodynamic responses.
Healthy female college students (n=23), moderate caffeine consumers (<150 mg/day), BMI 25-32.5, ages 18-40.
12-hour fast and 24-hour exercise abstinence. Baseline measures followed by treatment or placebo, then repeat testing at 30, 60, 120, 180 minutes.
Each participant completed two sessions with at least 7 days between visits, receiving the opposite condition at the second visit.
REE increased after OxyShred ingestion and decreased after placebo. Mean increases ranged from 121 to 166 kcal/day in the active condition across time points.
Hemodynamics refers to how blood flows through your body - mainly blood pressure and heart rate. In this study, systolic blood pressure rose slightly (about 3-4 mmHg) after the active supplement and stayed in normal ranges, with no adverse responses reported.
Respiratory quotient decreased at 120 and 180 minutes in both conditions, suggesting a shift toward fat oxidation during the test window.
Free fatty acids increased after OxyShred, with higher values versus placebo at 30 minutes, and again at 60 and 180 minutes.
Subjective fatigue decreased in the active condition; other mood measures did not change significantly.
The supplement increased resting energy expenditure for a few hours, which means participants burned a bit more energy at rest during the test window. This is a short-term effect and does not, by itself, prove long-term fat loss.
Blood pressure and heart rate are basic safety checks. The small bump in systolic blood pressure suggests a mild stimulant effect in this short, controlled setting.
Lower respiratory quotient indicates a shift toward fat use during the test window, but it happened in both the supplement and placebo sessions, so it may reflect fasting and time-of-test rather than the product alone.
Participants reported less fatigue after the supplement, which can feel like more energy. Other mood measures were unchanged.
The proprietary matrix includes acetyl L-carnitine HCl, Garcinia cambogia extract, conjugated linoleic acid, grapefruit seed extract, raspberry ketones, Mangifera indica seed extract, bitter orange, green coffee bean extract, olive leaf extract, guggul extract, and chromium picolinate. The study evaluates the combined product, not each ingredient independently.
Explanatory context (not claims from the study): these ingredients are commonly used in thermogenic or \"fat-burning\" blends and are typically marketed for metabolic support, appetite control, or energy. Evidence varies by ingredient and formulation.
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